| KGF在人NSCLC中的表达及意义 |
| 作者：刘领，笪… 文章来源：《中国癌症杂志》 点击数： 更新时间：2005-5-17 |
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[摘要] 目的：探讨KGF mRNA之于肺癌，尤其是非小细胞肺癌（NSCLC）发生的意义。
方法：采用原位杂交法检测KGF mRNA在50例非小细胞肺癌中的表达，并将其与正常组织对照。
结果：NSCLC中KGF mRNA阳性率达86%，明显高于正常肺组织（P＜0.05），KGF mRNA阳性主要表现为间质细胞细胞质着色，少数肿瘤实质细胞细胞质亦有着色。
结论：NSCLC中存在KGF mRNA高表达。KGF可通过旁分泌、自分泌两种方式发挥作用。KGF可能与上皮源性的NSCLC的发生相关。
[关键词] 角质细胞生长因子；非小细胞肺癌；原位杂交
[Abstract] Purpose：To investigate expression of keratinocyte growth factor(KGF) messenger ribonuclunc acid in human NSCLC and to study the role of KGF in the development of NSCLC.
Methods：The expression of KGF mRNA in 50 cases with NSCLC was detected by in situ hybridization (ISH).
Results：On ISH slides, positive KGF mRNA was mainly shown as fusiform stain in plasma of fibroblast and blood vessel smooth muscle cell in mesenchymal of NSCLC, also, some parenchyma cell plasma was stained. The positive rate of KGF mRNA in tumor(86%) is statistically higher than that in normal tissue(24%)(P＜0.05).
Conclusions：KGF mRNA is highly expressed in NSCLC. Through paracine and autocrine way, KGF is possibly involved in the development of NSCLC, which is a carcinoma of epithelial origin.
[Key words] keratinocyte growth factor (KGF);non-small cell lung cancer(NSCLC);in situ hybridization (ISH)
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